Conde Délio Marques, Silva Emanuela T, Amaral Waldemar N, Finotti Marta F, Ferreira Rui G, Costa-Paiva Lúcia, Pinto-Neto Aarão M
Department of Gynecology and Obstetrics, Universidade Federal de Goiás, Goiânia, Brazil.
Menopause. 2009 Jan-Feb;16(1):199-213. doi: 10.1097/gme.0b013e318177352c.
Infection by the human immunodeficiency virus (HIV) is increasing among women. After the advent of highly active antiretroviral therapy (HAART), a decrease occurred in the mortality rate, which now seems to have stabilized. One of the consequences of this current situation is that more and more HIV-infected women are now reaching menopause. Therefore, factors often investigated in seronegative women need to be evaluated in middle-aged, HIV-positive women. In midlife, HIV-positive women will experience the onset of menopause, while concomitantly they may also be affected by metabolic complications related to the HIV infection and to HAART. This literature review was therefore carried out to identify studies dealing with conditions related to middle-aged women with HIV with the aim of providing data on age at menopause, menopausal symptoms, reproductive hormones, cognitive function, bone mineral density, cardiovascular disease, and lipid and glucose metabolism in middle-aged women with HIV and discussing these issues. Some of these factors may be aggravated by the HIV infection and by HAART. The prevention and treatment of these conditions in middle-aged, HIV-positive women are discussed in the light of current knowledge.
感染人类免疫缺陷病毒（HIV）的女性人数正在增加。高效抗逆转录病毒疗法（HAART）出现后，死亡率有所下降，目前似乎已趋于稳定。当前这种情况的一个后果是，越来越多感染HIV的女性进入更年期。因此，通常在血清阴性女性中研究的因素需要在中年HIV阳性女性中进行评估。在中年时期，HIV阳性女性会经历更年期的开始，与此同时，她们也可能受到与HIV感染和HAART相关的代谢并发症的影响。因此，进行了这项文献综述，以确定有关中年HIV感染女性状况的研究，目的是提供关于HIV感染中年女性的绝经年龄、更年期症状、生殖激素、认知功能、骨矿物质密度、心血管疾病以及脂质和葡萄糖代谢的数据，并讨论这些问题。其中一些因素可能会因HIV感染和HAART而加重。根据现有知识，对中年HIV阳性女性这些状况的预防和治疗进行了讨论。
