Rittirsch Daniel, Flierl Michael A, Ward Peter A
Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109-0602, USA.
Nat Rev Immunol. 2008 Oct;8(10):776-87. doi: 10.1038/nri2402.
Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and clinicians and are a tremendous burden for health-care systems. Despite extensive basic research and clinical studies, the pathophysiology of sepsis is still poorly understood. We are now beginning to understand that sepsis is a heterogeneous, dynamic syndrome caused by imbalances in the 'inflammatory network'. In this Review, we highlight recent insights into the molecular interactions that occur during sepsis and attempt to unravel the nature of the dysregulated immune response during sepsis.
脓毒症及脓毒症相关的多器官功能衰竭是科学家和临床医生面临的重大挑战，也是卫生保健系统的巨大负担。尽管进行了广泛的基础研究和临床研究，但脓毒症的病理生理学仍未得到充分理解。我们现在开始认识到，脓毒症是一种由“炎症网络”失衡引起的异质性、动态综合征。在本综述中，我们重点介绍了对脓毒症期间发生的分子相互作用的最新见解，并试图阐明脓毒症期间免疫反应失调的本质。
