铑催化环丙烯的氢甲酰化反应。

Rhodium-catalyzed hydroformylation of cyclopropenes.

作者信息

Sherrill William M, Rubin Michael

机构信息

Department of Chemistry, University of Kansas and Center for Environmentally Beneficial Catalysis, 1251 Wescoe Hall Drive, Malott Hall, Lawrence, Kansas 66045-7582, USA.

出版信息

J Am Chem Soc. 2008 Oct 15;130(41):13804-9. doi: 10.1021/ja805059f. Epub 2008 Sep 20.

DOI:10.1021/ja805059f

PMID:18803386

Abstract

The first catalytic diastereo- and enantioselective hydroformylation of cyclopropenes was demonstrated. The reaction proceeds efficiently under very mild conditions and low catalyst loadings providing high yields of cyclopropylcarboxaldehydes. This novel methodology represents a convenient, atom-economic approach toward optically active cyclopropylcarboxaldehydes from readily available prochiral cyclopropenes.

摘要

首次展示了环丙烯的催化非对映和对映选择性氢甲酰化反应。该反应在非常温和的条件下和低催化剂负载量下高效进行，可提供高产率的环丙基甲醛。这种新颖的方法代表了一种从易得的前手性环丙烯制备光学活性环丙基甲醛的便捷、原子经济的方法。