钙调蛋白激酶II在心肌生理学和疾病中的作用。
The role of calmodulin kinase II in myocardial physiology and disease.
作者信息
Couchonnal Luis F, Anderson Mark E
机构信息
Departments of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA.
出版信息
Physiology (Bethesda). 2008 Jun;23:151-9. doi: 10.1152/physiol.00043.2007.
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca(2+) homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca(2+) homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.
多功能的钙/钙调蛋白依赖性蛋白激酶II（CaMKII）调节心脏中多种下游靶点。钙稳态蛋白是支持心肌兴奋-收缩偶联的重要CaMKII靶点。在应激条件下，过量的CaMKII活性会促进心力衰竭和心律失常，部分原因是其作用于钙稳态蛋白。在此，我们简要综述心肌中CaMKII的分子和细胞生理学。
Zotero 插件