大环内酯类药物的误解
Macrolide myths.
作者信息
Mankin Alexander S
机构信息
Center for Pharmaceutical Biotechnology-m/c 870, University of Illinois at Chicago, 900 S. Ashland Avenue, Room 3052, Chicago, IL 60607, USA.
出版信息
Curr Opin Microbiol. 2008 Oct;11(5):414-21. doi: 10.1016/j.mib.2008.08.003. Epub 2008 Oct 3.
Abstract
In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'. This review focuses on certain aspects of binding and action of macrolides that may need re-evaluation in view of the new findings.
摘要
尽管经过了数十年的研究，但我们对大环内酯类抗生素与其核糖体靶点的相互作用模式以及这些药物的作用机制的了解仍然支离破碎。过去几年获得的实验事实对一些被视为“常识”的概念提出了质疑。鉴于这些新发现，本综述重点关注大环内酯类药物结合和作用的某些方面，这些方面可能需要重新评估。
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