Sperling Wolfgang, Bleich Stefan, Maihöfner Christian, Reulbach Udo
Department of Psychiatry and Psychotherapy, University Clinic of Erlangen, Schwabachanlage 6, 91052 Erlangen, Germany.
Med Hypotheses. 2009 Feb;72(2):213-6. doi: 10.1016/j.mehy.2008.09.005. Epub 2008 Sep 18.
Schizophrenia, with a lifetime prevalence of one percent, is one of the most common mental diseases. Regarding the typology and definition, hallucinations of different qualities (auditory, visual, tactile, olfactory and gustatory) represent a so-called core symptom according to the modern classification systems ICD-10 and DSM-IV. However, under functional imaging evaluation (MEG) of a neuronal correlate of the disease, truly asymmetric relationships were found. While the notable neurophysiological finding was a general slowing of delta-theta activity within the temporal lobe, an increase in beta activity was found within the same zone during auditory hallucinations, which raises the question of whether this might be an intermittent compensation mechanism of the brain, also in the sense of a self-healing function. This might lead one to speculate whether the supposed core symptom of the disease, auditory hallucination, is not in fact a possible resistance mechanism. If this hypothesis blurts out any measure of truth, the usual therapeutic algorithm will have to be re-evaluated.
精神分裂症的终生患病率为1%，是最常见的精神疾病之一。关于其类型学和定义，根据现代分类系统ICD - 10和DSM - IV，不同性质的幻觉（听觉、视觉、触觉、嗅觉和味觉）代表了一种所谓的核心症状。然而，在对该疾病的神经元相关性进行功能成像评估（MEG）时，发现了真正的不对称关系。显著的神经生理学发现是颞叶内δ-θ活动普遍减慢，而在听觉幻觉期间同一区域的β活动增加，这就提出了一个问题，即这是否可能是大脑的一种间歇性补偿机制，从自我修复功能的角度来看也是如此。这可能会让人推测，该疾病所谓的核心症状——听觉幻觉，实际上是否并非一种可能的抵抗机制。如果这个假设有任何真实性可言，那么通常的治疗算法将不得不重新评估。
