Chang Chih-Tsung, Patel Pranav, Kang Namin, Lawson John A, Song Wen-Liang, Powell William S, FitzGerald Garret A, Rokach Joshua
Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA.
Bioorg Med Chem Lett. 2008 Oct 15;18(20):5523-7. doi: 10.1016/j.bmcl.2008.09.008. Epub 2008 Sep 6.
The stereospecific synthesis of two all-syn-EPA-derived isoprostanes (iPs), 5-epi-8,12-iso-iPF(3alpha)-VI 17 and 8,12-iso-iPF(3alpha)-VI 18, has been accomplished. These two synthetic probes have been used to discover and identify their presence in human urine. The eventual quantitative measurement of these two iPs may be a valuable index of oxidative stress in people with eicosapentaenoic acid- (EPA) and docosahexaenoic acid- (DHA) enriched phospholipids.
两种全顺式二十碳五烯酸（EPA）衍生的异前列腺素（iP），即5-表-8,12-异-iPF(3α)-VI 17和8,12-异-iPF(3α)-VI 18的立体定向合成已经完成。这两种合成探针已被用于发现和鉴定它们在人类尿液中的存在。对这两种iP的最终定量测量可能是富含二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的磷脂人群氧化应激的一个有价值指标。
