Nourooz-Zadeh J, Liu E H, Yhlen B, Anggård E E, Halliwell B
Centre for Clinical Pharmacology and Therapeutic Toxicology, Department of Medicine, University College, London, England.
J Neurochem. 1999 Feb;72(2):734-40. doi: 10.1046/j.1471-4159.1999.0720734.x.
F2-isoprostanes are prostaglandin-like compounds derived from free radical-catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F3-isoprostanes, whereas peroxidation of docosahexaenoic acid would give F4-isoprostanes. This study demonstrates the presence of esterified F4-isoprostanes in human brain and shows that levels are elevated in certain brain cortex regions in Alzheimer's disease. Our data with Alzheimer's disease suggest that analysis of F4-isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.
F2-异前列腺素是一类类似前列腺素的化合物，由自由基催化花生四烯酸的过氧化反应生成。二十碳五烯酸的过氧化反应产生F3-异前列腺素，而二十二碳六烯酸的过氧化反应则生成F4-异前列腺素。本研究证实了人脑中存在酯化的F4-异前列腺素，并表明在阿尔茨海默病患者的某些脑皮质区域中其水平升高。我们关于阿尔茨海默病的数据表明，对F4-异前列腺素的分析将为研究神经退行性疾病中的脂质过氧化提供新的机会。
