童年期性虐待对大脑区域发育影响中敏感期的初步证据。
Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development.
作者信息
Andersen Susan L, Tomada Akemi, Vincow Evelyn S, Valente Elizabeth, Polcari Ann, Teicher Martin H
机构信息
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2008 Summer;20(3):292-301. doi: 10.1176/jnp.2008.20.3.292.
Abstract
Volumetric MRI scans from 26 women with repeated episodes of childhood sexual abuse and 17 healthy female comparison subjects (ages 18-22 years) were analyzed for sensitive period effects on hippocampal and amygdala volume, frontal cortex gray matter volume and corpus callosum area. Hippocampal volume was reduced in association with childhood sexual abuse at ages 3-5 years and ages 11-13 years. Corpus callosum was reduced with childhood sexual abuse at ages 9-10 years, and frontal cortex was attenuated in subjects with childhood sexual abuse at ages 14-16 years. Brain regions have unique windows of vulnerability to the effects of traumatic stress.
摘要
对26名有童年期性虐待反复经历的女性和17名健康女性对照受试者（年龄18 - 22岁）的容积性磁共振成像扫描进行了分析，以研究敏感期对海马体和杏仁核体积、额叶皮质灰质体积以及胼胝体面积的影响。海马体体积在3 - 5岁和11 - 13岁时因童年期性虐待而减小。胼胝体在9 - 10岁时因童年期性虐待而减小，额叶皮质在14 - 16岁有童年期性虐待经历的受试者中变薄。脑区对创伤性应激的影响有独特的易损期。
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