Geuze E, Vermetten E, Bremner J D
Department of Military Psychiatry, Central Military Hospital, Utrecht, Rudolf Magnus Institute of Neuroscience, Mailbox B.01.2.06, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Mol Psychiatry. 2005 Feb;10(2):147-59. doi: 10.1038/sj.mp.4001580.
The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.
神经成像技术的进步导致了大量研究的涌现，这些研究报告了多种神经精神疾病中脑结构和功能的异常。海马体体积测量已发展成为研究神经精神疾病的一种有用工具。我们回顾了文献，选择了所有关于海马体体积测量的英文、以人为研究对象、数据驱动的论文，建立了一个包含423条记录的数据库。从这个数据库中，研究了所有原始手动追踪方案的方法。这些方案在准确测定海马体体积的一些重要因素上存在差异，包括磁场强度、评估的切片数量和切片厚度、海马体方向校正、体积校正、使用的软件、评分者间信度以及海马体的解剖边界。本文将结合优化海马体体积测定的方法对这些发现进行讨论。
