Frye Richard E, Hasan Khader, Xue Lian, Strickland David, Malmberg Benjamin, Liederman Jacqueline, Papanicolaou Andrew
Department of Pediatrics, University of Texas Health Science Center, 7000 Fannin-UCT 2478, Houston, TX 77030, USA.
Neuroreport. 2008 Oct 29;19(16):1627-31. doi: 10.1097/WNR.0b013e328314b8ee.
Inconsistent differences in the corpus callosum (CC) structure between dyslexic readers (DRs) and typical readers (TRs) have been reported. We examine differences in CC splenium microstructure and the association of splenium microstructure with reading-related skills. Nine DRs and 18 TRs completed a reading skills battery and diffusion tensor imaging. DRs had higher splenium fractional anisotropy (FA) and axial diffusivity (LA) as compared with TRs. Retrieval of orthographic information from the language lexicon was negatively associated with FA and LA within both reading groups. Phonological awareness was positively associated with splenium FA and LA in TRs but not DRs. This study suggests two white matter pathways that may be differentially associated with reading skills in the CC splenium.
据报道,阅读障碍者(DRs)与正常阅读者(TRs)之间胼胝体(CC)结构存在不一致的差异。我们研究了胼胝体压部微观结构的差异以及压部微观结构与阅读相关技能的关联。9名阅读障碍者和18名正常阅读者完成了一套阅读技能测试和扩散张量成像。与正常阅读者相比,阅读障碍者的压部各向异性分数(FA)和轴向扩散率(LA)更高。在两个阅读组中,从语言词典中检索正字法信息与FA和LA呈负相关。语音意识在正常阅读者中与压部FA和LA呈正相关,但在阅读障碍者中并非如此。本研究提示了两条可能与胼胝体压部阅读技能存在差异关联的白质通路。