Du Xiao Fei, Jiang Cheng Zhe, Wu Chun Fu, Won Eun Kyung, Choung Se Young
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Arch Pharm Res. 2008 Sep;31(9):1153-9. doi: 10.1007/s12272-001-1282-6. Epub 2008 Sep 20.
We investigated the synergistic effect of combined treatment with red ginseng acidic polysaccharide (RGAP) from Panax ginseng C.A. Meyer and pidotimod in cyclophosphamide-treated mice. The combination of pidotimod and RGAP restored concanavalin A-induced splenic T cell proliferation and LPS-stimulated B cell proliferation significantly. The production of nitric oxide from peritoneal macrophages was increased by the combinations. NK cell activity was increased by RGAP alone or in combination with pidotimod. A synergistic increase in the level of serum IL-12 and interferongamm was observed when the combination of the two was used. RGAP alone or in combination with pidotimod modulated the level of serum C-reactive protein to a near-normal level. These results indicate that combinations of pidotimod and RGAP are synergistic and suggest that combination therapy using pidotimod and RGAP for improving immune activity may provide an additional benefit over the use of the two drugs by themselves.
我们研究了人参（Panax ginseng C.A. Meyer）中提取的红参酸性多糖（RGAP）与匹多莫德联合治疗对环磷酰胺处理小鼠的协同作用。匹多莫德与RGAP联合使用可显著恢复伴刀豆球蛋白A诱导的脾T细胞增殖以及脂多糖刺激的B细胞增殖。联合用药可增加腹膜巨噬细胞一氧化氮的产生。单独使用RGAP或与匹多莫德联合使用均可提高自然杀伤细胞活性。当二者联合使用时，血清白细胞介素-12和干扰素-γ水平出现协同性升高。单独使用RGAP或与匹多莫德联合使用可将血清C反应蛋白水平调节至接近正常水平。这些结果表明，匹多莫德与RGAP联合使用具有协同作用，提示使用匹多莫德和RGAP联合治疗以改善免疫活性可能比单独使用这两种药物具有更多益处。
