Graser A, Becker C R, Reiser M F, Stief C, Staehler M
Institut für Klinische Radiologie, Klinikum Grosshadern der Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 München, Deutschland.
Radiologe. 2008 Sep;48(9):850-6. doi: 10.1007/s00117-008-1743-5.
For patients with metastasized renal cell carcinoma (RCC), imaging techniques are of great importance. Currently, therapy widely relies on antiangiogenic factors, which frequently lead to relatively subtle changes in the size of lesions. From this aspect the commonly used RECIST criteria (response evaluation criteria in solid tumors) must be considered as imprecise for the evaluation of the response to therapy. This article gives a review on new software-based volumetric methods, which allow therapy-induced changes in the size of metastases from RCC to be detected with higher sensitivity and reproducibility. A comparison of RECIST and volumetry was carried out with data from patients with metastasized RCC to demonstrate the higher sensitivity of the 3D volumetric procedure.
对于转移性肾细胞癌（RCC）患者，成像技术至关重要。目前，治疗广泛依赖抗血管生成因子，这常常导致病变大小出现相对细微的变化。从这方面来看，常用的实体瘤疗效评价标准（RECIST）在评估治疗反应时必须被视为不够精确。本文对基于软件的新体积测量方法进行了综述，这些方法能够以更高的灵敏度和可重复性检测出RCC转移灶大小因治疗引起的变化。利用转移性RCC患者的数据对RECIST和体积测量法进行了比较，以证明三维体积测量法具有更高的灵敏度。
