纤维蛋白密封剂与缝合线固定补片导致的粘连分析：实验性腹腔内模型

Analysis of adhesions resulted from mesh fixation with fibrin sealant and suture: experimental intraperitoneal model.

作者信息

Montes Juliano Hermes Maeso, Bigolin André Vicente, Baú Renata, Nicola Roberto, Grossi João Vicente Machado, Loureiro Cláudia Juliana, Cavazzola Leandro Totti

机构信息

Experimental Laboratory, Institute for Basic Health Sciences, Lutheran University of Brazil (ULBRA), Brazil.

出版信息

Rev Col Bras Cir. 2012 Dec;39(6):509-14. doi: 10.1590/s0100-69912012000600011.

DOI:10.1590/s0100-69912012000600011

PMID:23348648

Abstract

OBJECTIVE

To compare surgical fixation of polypropylene mesh (PP) and coated polypropylene mesh (PCD) using polypropylene suture and fibrin glue, as for the formation of intraperitoneal adhesions.

METHODS

A sample of 46 female Wistar rats were randomized into six groups: two control groups, with five rats each, were subjected to one medial incision (MI) and the other to a U-shaped incision (UI), none of these groups received the mesh. Two groups of PP mesh, with ten rats, fixed with suture (PPF), the other with six rats, fixed with biological glue (PPC). And two groups of PCD mesh, at first, with ten animals, the mesh was fixed with sutures (PCDFs) and the second with ten animals with biological glue (PCDC).

RESULTS

After 21 days, the control groups showed no significant adhesions. The PPC group showed a lower degree of adhesion than the PPF group (p = 0.01). There was no difference between the groups with PCD.

CONCLUSION

Comparison of fixation was statistically different only with PP mesh, with lesser degrees of adherence when using the glue. Adhesions were predominantly located at the extremities of the meshes studied.

摘要

目的

比较使用聚丙烯缝线和纤维蛋白胶对聚丙烯网片（PP）和涂层聚丙烯网片（PCD）进行手术固定后腹腔粘连的形成情况。

方法

将46只雌性Wistar大鼠随机分为六组：两个对照组，每组五只大鼠，分别进行一次正中切口（MI）和另一次U形切口（UI），这些组均未接受网片。两组PP网片，每组十只大鼠，用缝线固定（PPF），另一组六只大鼠，用生物胶固定（PPC）。两组PCD网片，第一组十只动物，网片用缝线固定（PCDFs），第二组十只动物，用生物胶固定（PCDC）。