余甘子治疗对四氯化碳诱导的肝毒性大鼠肝脏、肾脏和睾丸的影响。
Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats.
作者信息
Manjrekar A P, Jisha V, Bag P P, Adhikary B, Pai M M, Hegde A, Nandini M
机构信息
Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore 575 004, India.
出版信息
Indian J Exp Biol. 2008 Jul;46(7):514-20.
Phyllanthus niruri extract is extensively used in treating liver ailments. Effects of aqueous extract of P. niruri on liver, kidney and testes of CCl4 induced hepatotoxic rats were studied. High levels of malondialdehyde (MDA) were observed in the CCl4 test group with significant reduction of MDA levels in all groups on P. niruri extract administration. Highest levels of glutathione (GSH) were found in P. niruri group. Activities of alanine transaminase, aspartate transaminase and alkaline phosphatase enzymes were significantly reduced in the curative group (P. niruri treatment after CCl4 injection). Histopathology of liver showed lesser degree of inflammation in all P. niruri treated groups while the renal and seminiferous tubules showed eosinophilic protein casts with signs of tubular damage and degeneration. Testes also showed decreased amount of mature spermatozoa. The results suggest that P. niruri has anti-oxidant and hepato-protective activity with associated deleterious effects on kidney and testes.
叶下珠提取物被广泛用于治疗肝脏疾病。研究了叶下珠水提取物对四氯化碳诱导的肝毒性大鼠肝脏、肾脏和睾丸的影响。在四氯化碳试验组中观察到高水平的丙二醛（MDA），而在给予叶下珠提取物的所有组中，MDA水平显著降低。叶下珠组中谷胱甘肽（GSH）水平最高。在治疗组（四氯化碳注射后给予叶下珠治疗）中，丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶的活性显著降低。肝脏组织病理学显示，所有叶下珠治疗组的炎症程度较轻，而肾小管和曲细精管显示嗜酸性蛋白管型，伴有肾小管损伤和变性的迹象。睾丸中成熟精子的数量也减少。结果表明，叶下珠具有抗氧化和肝脏保护活性，但对肾脏和睾丸有相关的有害影响。
Zotero 插件