Ma Hui, Wang Lili, Zhang Chunxiao, Yi Hong
College of Bioscience and Bioengineering, Hebei University of Science & Technology, Shijiazhuang 050018, China.
Sheng Wu Gong Cheng Xue Bao. 2008 Jun;24(6):927-32.
Vitamin B12 is an important nutrient widely used in feed, food and medicine field. China is the primary producing area and the VB12 production is 27 t in 2007, 77% of total production in the world. VB12 is the most complex small molecule difficult to chemosynthesize. It ismanufactured by bacteria and archaea via two alternative routes, aerobic or anaerobic pathway. The main strains used in industry fermentation are Propionibacterium freudenrechii and Pseudomonas denitrificans. The basic characteristics, biosynthesis and fermentation of vitamin B12 are reviewed. The vitamin B12 application and market are also summarized.
维生素B12是一种重要的营养素，广泛应用于饲料、食品和医药领域。中国是主要生产地区，2007年维生素B12产量为27吨，占世界总产量的77%。维生素B12是最难化学合成的最复杂小分子。它由细菌和古生菌通过两条替代途径，即需氧或厌氧途径合成。工业发酵中使用的主要菌株是费氏丙酸杆菌和反硝化假单胞菌。本文综述了维生素B12的基本特性、生物合成和发酵。还总结了维生素B12的应用和市场情况。
