人类受试者中DuraGen的组织学分析：病例报告
Histological analysis of DuraGen in a human subject: case report.
作者信息
Khorasani L, Kapur R P, Lee C, Avellino A M
机构信息
Division of Pediatric Neurosurgery, Children's Hospital and Regional Medical Center, Seattle, WA, USA.
出版信息
Clin Neuropathol. 2008 Sep-Oct;27(5):361-4. doi: 10.5414/npp27361.
OBJECT
DuraGen (Integra Neurosciences, Plainsboro, NJ, USA) is an avascular collagen matrix used for dural closure. Although, numerous animal models have been studied, histological transformation of DuraGen in humans has not been reported.
MATERIAL AND METHOD
We analyzed a sample of scarred DuraGen used in a craniectomy patient at time of delayed cranioplasty.
CONCLUSION
Histological analysis revealed evidence for both fibroblast infiltration and neovascularization of the DuraGen.
目的
DuraGen（美国新泽西州普兰斯伯勒市Integra神经科学公司生产）是一种用于硬脑膜闭合的无血管胶原基质。尽管已经对众多动物模型进行了研究，但尚未有关于DuraGen在人体组织学转变的报道。
材料与方法
我们分析了一名颅骨切除术患者在延迟颅骨成形术时使用的瘢痕化DuraGen样本。
结论
组织学分析显示DuraGen存在成纤维细胞浸润和新生血管形成的证据。
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