老年人贫血的流行病学
Epidemiology of anemia in older adults.
作者信息
Patel Kushang V
机构信息
Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA.
出版信息
Semin Hematol. 2008 Oct;45(4):210-7. doi: 10.1053/j.seminhematol.2008.06.006.
Abstract
Anemia is a common, multifactorial condition among older adults. The World Health Organization (WHO) definition of anemia (hemoglobin concentration <12 g/dL in women and <13 g/dL in men) is most often used in epidemiologic studies of older adults. More than 10% of community-dwelling adults age 65 years and older has WHO-defined anemia. After age 50 years, prevalence of anemia increases with advancing age and exceeds 20% in those 85 years and older. In nursing homes, anemia is present in 48% to 63% of residents. Incidence of anemia in older adults is not well characterized. Among older adults with anemia, approximately one third have evidence of iron, folate, and/or vitamin B(12) deficiency, another third have renal insufficiency and/or chronic inflammation, and the remaining third have anemia that is unexplained. Several studies demonstrate that anemia is associated with poorer survival in older adults. This review details the distribution and consequences of anemia in older adults and identifies future epidemiologic research needs.
摘要
贫血是老年人中常见的多因素病症。世界卫生组织（WHO）对贫血的定义（女性血红蛋白浓度<12 g/dL，男性血红蛋白浓度<13 g/dL）在老年人流行病学研究中最为常用。65岁及以上社区居住成年人中超过10%患有WHO定义的贫血。50岁以后，贫血患病率随年龄增长而增加，85岁及以上人群中超过20%患有贫血。在养老院中，48%至63%的居民患有贫血。老年人贫血的发病率尚无明确特征。在患有贫血的老年人中，约三分之一有铁、叶酸和/或维生素B12缺乏的证据，另有三分之一有肾功能不全和/或慢性炎症，其余三分之一患有不明原因的贫血。多项研究表明，贫血与老年人较差的生存率相关。本综述详细阐述了老年人贫血的分布和后果，并确定了未来流行病学研究的需求。
相似文献
1
Epidemiology of anemia in older adults.老年人贫血的流行病学
Semin Hematol. 2008 Oct;45(4):210-7. doi: 10.1053/j.seminhematol.2008.06.006.
2
Micronutrient Deficiencies, Over- and Undernutrition, and Their Contribution to Anemia in Azerbaijani Preschool Children and Non-Pregnant Women of Reproductive Age.微量营养素缺乏、营养过剩和不足以及它们对阿塞拜疆学龄前儿童和育龄非孕妇贫血的影响。
Nutrients. 2018 Oct 11;10(10):1483. doi: 10.3390/nu10101483.
3
The prevalence of anemia, iron, vitamin B12, and folic acid deficiencies in community dwelling elderly in Ankara, Turkey.土耳其安卡拉社区居住老年人贫血、铁、维生素B12和叶酸缺乏症的患病率。
Arch Gerontol Geriatr. 2015 Mar-Apr;60(2):344-8. doi: 10.1016/j.archger.2015.01.001. Epub 2015 Jan 14.
4
Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic.在一个来自转诊贫血诊所的、种族多样化的老年人群体中，尽管进行了深入的评估，但仍以不明原因的贫血为主。
J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):925-32. doi: 10.1093/gerona/glr090. Epub 2011 Jun 9.
5
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia.美国65岁及以上人群贫血患病率：不明原因贫血高发生率的证据。
Blood. 2004 Oct 15;104(8):2263-8. doi: 10.1182/blood-2004-05-1812. Epub 2004 Jul 6.
6
Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I.社区老年残疾女性中的贫血类型与死亡率：女性健康与衰老研究I
Aging Clin Exp Res. 2007 Aug;19(4):259-64. doi: 10.1007/BF03324699.
7
Anemia, Micronutrient Deficiencies, and Malaria in Children and Women in Sierra Leone Prior to the Ebola Outbreak - Findings of a Cross-Sectional Study.埃博拉疫情爆发前塞拉利昂儿童和妇女的贫血、微量营养素缺乏与疟疾——一项横断面研究的结果
PLoS One. 2016 May 10;11(5):e0155031. doi: 10.1371/journal.pone.0155031. eCollection 2016.
8
Epidemiology of chronic kidney disease and anemia.慢性肾脏病与贫血的流行病学
J Am Med Dir Assoc. 2006 Nov;7(9 Suppl):S3-6; quiz S17-21. doi: 10.1016/j.jamda.2006.09.004.
9
Prevalence of anemia in Chinese nursing home older adults: implication of age and renal impairment.中国养老院老年人贫血的患病率：年龄和肾功能损害的影响。
Geriatr Gerontol Int. 2013 Jul;13(3):591-6. doi: 10.1111/j.1447-0594.2012.00942.x. Epub 2012 Sep 19.
10
Factor deficiency in the anemia of renal transplant patients with grade III-IV chronic kidney disease: baseline results of the ARES Study.III-IV 级慢性肾病肾移植患者贫血中的因子缺乏：ARES 研究的基线结果
Transplant Proc. 2008 Nov;40(9):2922-4. doi: 10.1016/j.transproceed.2008.08.083.
引用本文的文献
1
Balancing Environmental Sustainability and Nutrition: Dietary Climate Impact in Relation to Micronutrient Intake and Status in a Swedish Cohort.平衡环境可持续性与营养：瑞典队列中饮食的气候影响与微量营养素摄入及状况的关系
Curr Dev Nutr. 2025 Jul 5;9(8):107501. doi: 10.1016/j.cdnut.2025.107501. eCollection 2025 Aug.
2
Comparative analysis of outcomes between anemic and non-anemic critically ill elderly patients in a geriatric ICU in Egypt: A focused study.埃及一家老年重症监护病房中贫血与非贫血老年重症患者结局的比较分析：一项重点研究。
J Crit Care Med (Targu Mures). 2025 Jul 31;11(3):290-300. doi: 10.2478/jccm-2025-0028. eCollection 2025 Jul.
3
Transcatheter Aortic Valve Replacement Reverses Heyde Syndrome: A Case Report of Severe Aortic Stenosis and Gastrointestinal Bleeding.经导管主动脉瓣置换术逆转海德综合征：一例严重主动脉瓣狭窄合并胃肠道出血的病例报告
J Clin Med. 2025 Apr 19;14(8):2819. doi: 10.3390/jcm14082819.
4
Prevalence and sociodemographic determinants of anemia among ever-married women of reproductive age in Jordan: insights from the 2023 Jordan population and family health survey.约旦育龄已婚女性贫血的患病率及社会人口学决定因素：来自2023年约旦人口与家庭健康调查的见解
BMC Public Health. 2025 Apr 25;25(1):1537. doi: 10.1186/s12889-025-22578-7.
5
Iron deficiency anemia-related mortality trends in US older subjects, 1999 to 2019.1999年至2019年美国老年受试者缺铁性贫血相关死亡率趋势
Aging Clin Exp Res. 2025 Mar 22;37(1):99. doi: 10.1007/s40520-025-02982-0.
6
Macrocytic anemia, kidney dysfunction, and mortality in general population: Japan specific health checkup study.一般人群中的大细胞性贫血、肾功能不全与死亡率：日本特定健康检查研究
Sci Rep. 2024 Dec 30;14(1):32005. doi: 10.1038/s41598-024-83547-5.
7
Application of laboratory frailty index in predicting delirium in elderly patients with community-acquired pneumonia.实验室衰弱指数在预测老年社区获得性肺炎患者谵妄中的应用。
Front Aging. 2024 Dec 16;5:1478355. doi: 10.3389/fragi.2024.1478355. eCollection 2024.
8
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function.认知功能正常的老年人的葡萄糖代谢与较小的海马体体积
NPJ Aging. 2024 Sep 9;10(1):39. doi: 10.1038/s41514-024-00164-2.
9
Impact of Anemia on Cardiovascular Events and All-Cause Death Among Participants Who Received Intense Blood Pressure Treatment: A Secondary Analysis of SPRINT.接受强化血压治疗的参与者中贫血对心血管事件和全因死亡的影响：收缩压干预试验（SPRINT）的二次分析
Rev Cardiovasc Med. 2024 Jan 8;25(1):6. doi: 10.31083/j.rcm2501006. eCollection 2024 Jan.
10
Establishing reference intervals for common hematology test parameters from apparently healthy geriatrics in Asella town, Southeast Ethiopia, 2020: a community-based cross-sectional study.2020年埃塞俄比亚东南部阿塞拉镇明显健康的老年人常见血液学检测参数参考区间的建立：一项基于社区的横断面研究
Front Med (Lausanne). 2024 May 16;11:1373283. doi: 10.3389/fmed.2024.1373283. eCollection 2024.
本文引用的文献
1
Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure.慢性心力衰竭门诊患者新发、短暂性和持续性贫血的评估及长期预后
J Am Coll Cardiol. 2008 Feb 5;51(5):569-76. doi: 10.1016/j.jacc.2007.07.094.
2
Epidemiology of myelodysplastic syndromes.骨髓增生异常综合征的流行病学
Semin Hematol. 2008 Jan;45(1):8-13. doi: 10.1053/j.seminhematol.2007.10.003.
3
Prevalence of anemia in the nursing home: contribution of chronic kidney disease.养老院中贫血的患病率：慢性肾脏病的影响
J Am Geriatr Soc. 2007 Oct;55(10):1566-70. doi: 10.1111/j.1532-5415.2007.01389.x. Epub 2007 Aug 28.
4
Anemia status, hemoglobin concentration, and mortality in nursing home older residents.疗养院老年居民的贫血状况、血红蛋白浓度与死亡率
J Am Med Dir Assoc. 2007 Jun;8(5):322-7. doi: 10.1016/j.jamda.2007.01.028. Epub 2007 May 7.
5
Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers.老年人不明原因贫血的特征是促红细胞生成素水平低和促炎标志物水平低。
Br J Haematol. 2007 Mar;136(6):849-55. doi: 10.1111/j.1365-2141.2007.06502.x.
6
Racial variation in the relationship of anemia with mortality and mobility disability among older adults.老年人中贫血与死亡率及行动能力残疾关系的种族差异。
Blood. 2007 Jun 1;109(11):4663-70. doi: 10.1182/blood-2006-10-055384. Epub 2007 Feb 6.
7
Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study.无慢性肾脏病老年人的肾功能与炎症标志物：健康、衰老与身体成分研究
Kidney Int. 2007 Feb;71(3):239-44. doi: 10.1038/sj.ki.5002042. Epub 2006 Dec 20.
8
Hematologic reference values for African American children and adolescents.
Am J Hematol. 2007 Jul;82(7):611-4. doi: 10.1002/ajh.20848.
9
Low testosterone levels and the risk of anemia in older men and women.老年男性和女性的低睾酮水平与贫血风险
Arch Intern Med. 2006 Jul 10;166(13):1380-8. doi: 10.1001/archinte.166.13.1380.
10
Anemia in old age is associated with increased mortality and hospitalization.老年人贫血与死亡率和住院率增加相关。
J Gerontol A Biol Sci Med Sci. 2006 May;61(5):474-9. doi: 10.1093/gerona/61.5.474.
Zotero 插件