Mucida Daniel, Park Yunji, Cheroutre Hilde
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Semin Immunol. 2009 Feb;21(1):14-21. doi: 10.1016/j.smim.2008.08.001. Epub 2008 Sep 21.
The vitamin A metabolites, including retinoic acid (RA), form ligands for retinoic acid-related nuclear receptors and together they play pleiotropic roles in various biological processes. Recently, we described that RA also functions as a key modulator of transforming growth factor-beta (TGF-beta)-driven immune deviation, capable of suppressing the differentiation of interleukin-17 secreting T helper cells (T(H)17) and conversely promoting the generation of Foxp3(+) T regulatory (Treg) cells. This review will focus on the role of RA in the reciprocal TGF-beta-driven differentiation of T(H)17 and Treg and on the importance of such regulatory mechanism to control a functional immune system, in particular at the mucosal interface of the intestine.
维生素A代谢产物，包括视黄酸（RA），可形成视黄酸相关核受体的配体，它们共同在各种生物学过程中发挥多效性作用。最近，我们描述了RA还是转化生长因子-β（TGF-β）驱动的免疫偏离的关键调节因子，能够抑制分泌白细胞介素-17的辅助性T细胞（Th17）的分化，反之促进Foxp3（+）调节性T细胞（Treg）的生成。本综述将聚焦于RA在TGF-β驱动的Th17和Treg相互分化中的作用，以及这种调节机制对于控制功能性免疫系统，特别是在肠道黏膜界面的重要性。
