Read P, Abbott R, Pantelidis P, Peters B S, White J A
Department of Genitourinary Medicine, St Thomas' Hospital, Lambeth Palace Road, London SE17EH, UK.
Sex Transm Infect. 2008 Oct;84(5):348-9. doi: 10.1136/sti.2008.030817.
Disseminated gonococcal infection (DGI) often presents a diagnostic challenge. Through the novel application of molecular technology, a case is presented that suggests how the diagnostic sensitivity for this systemic complication of gonococcal infection can be improved. In a typical case of DGI seen in a homosexual man in whom all mucosal and blood specimens were culture negative, nucleic acid amplification testing (NAAT) helped to confirm the diagnosis. Both throat and skin lesion specimens tested positive for gonococcal DNA and this was confirmed with a supplementary porA pseudogene NAAT. The use of adjuvant NAAT assessment is recommended as part of the diagnostic work-up for suspected DGI cases.
播散性淋球菌感染（DGI）常常带来诊断挑战。通过分子技术的新应用，本文呈现了一个病例，该病例提示了如何提高对淋球菌感染这种全身并发症的诊断敏感性。在一名同性恋男性的典型DGI病例中，所有黏膜和血液标本培养均为阴性，核酸扩增检测（NAAT）有助于确诊。咽喉和皮肤病变标本的淋球菌DNA检测均呈阳性，这通过补充的porA假基因NAAT得到了证实。对于疑似DGI病例，建议使用辅助NAAT评估作为诊断检查的一部分。
