罪名成立：一例焦谷氨酸酸中毒患者中未测定的尿阴离子

Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis.

作者信息

Rolleman E J, Hoorn E J, Didden P, Zietse R

机构信息

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.

出版信息

Neth J Med. 2008 Sep;66(8):351-3.

PMID:18809984

Abstract

A patient developed an unexplained metabolic acidosis with the characteristics of renal tubular acidosis. By correcting the serum anion gap for hypoalbuminaemia and analysing the urinary anions and cations, the presence of unmeasured anions was revealed. The diagnosis of pyroglutamic acidosis, caused by a combination of flucloxacillin and acetaminophen, was established. Strategies for solving complex cases of metabolic acidosis are discussed.

摘要

一名患者出现了具有肾小管酸中毒特征的不明原因代谢性酸中毒。通过校正低白蛋白血症时的血清阴离子间隙并分析尿阴离子和阳离子，发现了未测定阴离子的存在。确诊为由氟氯西林和对乙酰氨基酚联合导致的焦谷氨酸酸中毒。文中讨论了解决复杂代谢性酸中毒病例的策略。