Amer Halima, Dockery Frances, Barrett Nicholas, George Marc, Witek Karolina, Stanton Jeremy, Back Diane
Department of Ageing and Health, Guy's and St. Thomas' Foundation Trust, London, UK.
BMJ Case Rep. 2011 Jul 20;2011:bcr0520114292. doi: 10.1136/bcr.05.2011.4292.
The authors report two cases of pyroglutamic acidosis as a result of paracetamol and flucloxacillin therapy in patients with prosthesis infection following hemiarthroplasty for neck of femur fractures. Pyroglutamic acidosis is an important and often unrecognised cause of refractory metabolic acidosis that disproportionately affects older women, and can be caused by drugs such as paracetamol and flucloxacillin in the setting of sepsis, renal failure and malnutrition. Although relatively rare, the widespread use of these drugs in orthopaedic patients confirms the importance of this disorder.
作者报告了两例因对乙酰氨基酚和氟氯西林治疗导致的焦谷氨酸酸中毒病例，这些病例发生在股骨颈骨折半关节置换术后假体感染的患者中。焦谷氨酸酸中毒是难治性代谢性酸中毒的一个重要且常未被认识的原因，对老年女性影响尤为严重，在脓毒症、肾衰竭和营养不良的情况下，可由对乙酰氨基酚和氟氯西林等药物引起。尽管相对罕见，但这些药物在骨科患者中的广泛使用证实了这种病症的重要性。
