肝硬化合并肝性脑病患者苍白球改变及脑萎缩：一项磁共振成像研究

Globus pallidus alterations and brain atrophy in liver cirrhosis patients with encephalopathy: an MR imaging study.

作者信息

Zeneroli M L, Cioni G, Crisi G, Vezzelli C, Ventura E

机构信息

Clinica Medica III dell'Universitá di Modena, Italy.

出版信息

Magn Reson Imaging. 1991;9(3):295-302. doi: 10.1016/0730-725x(91)90414-h.

DOI:10.1016/0730-725x(91)90414-h

PMID:1881246

Abstract

Brain magnetic resonance (MR) was performed in 29 liver cirrhosis patients without (N = 10) and with hepatic encephalopathy (HE) of chronic recurrent (N = 10) and of chronic persistent (N = 9) type. Sixty percent of the patients with chronic recurrent HE and 100% of the patients with chronic persistent HE showed a bilateral and symmetrical hyperintensity of the globus pallidus in the T1-weighted images while the T2-weighted images were normal, suggesting the possibility of the accumulation of a paramagnetic compound in this brain area during HE. Other findings of the study were evidence of brain atrophy of mild or moderate degree in 70% of patients with chronic recurrent HE and in 77% with chronic persistent HE and patients with liver cirrhosis without HE appeared normal on MR examination.

摘要

对29例肝硬化患者进行了脑磁共振成像（MR）检查，其中无肝性脑病（HE）的患者10例，慢性复发性HE患者10例，慢性持续性HE患者9例。慢性复发性HE患者中有60%、慢性持续性HE患者中有100%在T1加权图像上显示双侧苍白球对称性高信号，而T2加权图像正常，提示在HE期间该脑区可能有顺磁性化合物蓄积。该研究的其他发现是，70%的慢性复发性HE患者和77%的慢性持续性HE患者有轻度或中度脑萎缩证据，无HE的肝硬化患者MR检查显示正常。