Tanaka K, Gotoh F, Gomi S, Takashima S, Mihara B, Shirai T, Nogawa S, Nagata E
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan.
Neurosci Lett. 1991 Jun 10;127(1):129-32. doi: 10.1016/0304-3940(91)90911-c.
The effect of intravenous administration of NG-monomethyl-L-arginine (L-NMMA, 30 mg/kg), a specific inhibitor of nitric oxide synthesis, on local cerebral blood flow (lCBF) was examined in the rat using the [14C]iodoantipyrine autoradiographic method. L-NMMA induced a statistically significant reduction in lCBF in the cerebral cortices as well as in various deep structures of the brain. This reduction in lCBF was accompanied by a clear increase in mean arterial blood pressure, suggesting that the cerebral resistance vessels constricted significantly beyond the autoregulatory response following L-NMMA administration. These findings indicate that the basal cerebral circulation may be closely related to nitric oxide production.
采用[14C]碘安替比林放射自显影法，在大鼠中研究了一氧化氮合成特异性抑制剂——静脉注射NG-单甲基-L-精氨酸（L-NMMA，30mg/kg）对局部脑血流量（lCBF）的影响。L-NMMA导致大脑皮质以及脑内各种深部结构的lCBF出现具有统计学意义的降低。lCBF的这种降低伴随着平均动脉血压的明显升高，这表明在给予L-NMMA后，脑阻力血管的收缩显著超过了自身调节反应。这些发现表明，脑的基础循环可能与一氧化氮的产生密切相关。
