Tanaka K, Fukuuchi Y, Gomi S, Mihara B, Shirai T, Nogawa S, Nozaki H, Nagata E
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan.
Neuroreport. 1993 Mar;4(3):267-70. doi: 10.1097/00001756-199303000-00010.
The effect of intravenous administration of NG-monomethyl-L-arginine (L-NMMA, 30 mg kg-1), a specific inhibitor of nitric oxide (NO) synthesis, on the autoregulation of local cerebral blood flow (LCBF) was examined in the rat using the [14C]iodoantipyrine autoradiographic method. LCBF was significantly lower in various superficial regions such as the cerebral cortices and cerebellar cortex and in several deep brain regions in animals with haemorrhagic hypotension induced after L-NMMA infusion (the L-NMMA + HEM group) compared with animals without haemorrhagic hypotension after L-NMMA infusion (the L-NMMA group). The present findings suggest that NO synthesis may play a crucial role in the autoregulation of LCBF in response to a reduction in blood pressure in the cerebral cortices, cerebellar cortex and several deep brain regions.
采用[14C]碘代安替比林放射自显影法，在大鼠中研究了静脉注射一氧化氮（NO）合成特异性抑制剂NG-单甲基-L-精氨酸（L-NMMA，30 mg·kg-1）对局部脑血流（LCBF）自身调节的影响。与L-NMMA注射后无出血性低血压的动物（L-NMMA组）相比，L-NMMA注射后诱导出血性低血压的动物（L-NMMA + HEM组）的大脑皮质和小脑皮质等多个浅表区域以及几个深部脑区的LCBF显著降低。目前的研究结果表明，在大脑皮质、小脑皮质和几个深部脑区，NO合成可能在血压降低时LCBF的自身调节中起关键作用。
