从坚韧小皮伞液体培养物中分离得到的两种杯伞烷型二萜类化合物。

Two cyathane-type diterpenoids from the liquid culture of Strobilurus tenacellus.

作者信息

Shiono Yoshihito, Hiramatsu Fuminori, Murayama Tetsuya, Koseki Takuya, Funakoshi Takayuki

机构信息

Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.

出版信息

Chem Biodivers. 2008 Sep;5(9):1811-6. doi: 10.1002/cbdv.200890170.

DOI:10.1002/cbdv.200890170

PMID:18816532

Abstract

The structures of two new cyathane-type diterpenoids isolated from a liquid culture of Strobilurus tenacellus have been elucidated. The chemical structures of the new compounds 1 and 2 were identified as (12S)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene and (12R)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene, respectively, by spectral methods, including HR-EI-MS, and 1D- and 2D-NMR techniques. Compounds 1 and 2 show antimicrobial activity against Pseudomonas aeruginosa. In addition, both compounds were also tested for activity against human cancer cells, and 2 showed growth inhibitory activity against YMB and COLO 201 cells.

摘要

从韧盖菇液体培养物中分离出的两种新的杯伞烷型二萜类化合物的结构已得到阐明。通过包括高分辨电子轰击质谱（HR-EI-MS）以及一维和二维核磁共振（1D-和2D-NMR）技术在内的光谱方法，新化合物1和2的化学结构分别被鉴定为(12S)-11α,14α-环氧-13α,14β,15-三羟基杯伞-3-烯和(12R)-11α,14α-环氧-13α,14β,15-三羟基杯伞-3-烯。化合物1和2对铜绿假单胞菌显示出抗菌活性。此外，还对这两种化合物针对人类癌细胞的活性进行了测试，化合物2对YMB和COLO 201细胞显示出生长抑制活性。