Zhu Shaoli, Li Fei, Du Chunlei, Fu Yongqi
Institute of Optics & Electronics, Chinese Academy of Sciences, Chengdu 610209, Sichuan Province, People's Republic of China.
Nanomedicine (Lond). 2008 Oct;3(5):669-77. doi: 10.2217/17435889.3.5.669.
A new silver (Ag) nanostructure with a rectangular distribution array composed of rhombic nanoparticles is described here. The structure has an apparent advantage of strong hot spots that have a much higher signal intensity than that of the previously reported traditional triangular structures. It generates a great enhancement of a localized surface plasmon resonance (LSPR) effect. Moreover, an antigen with longer arm length is applied to strengthen the binding signals of both the antigen and antibody. We performed experiments for the LSPR-induced extinction spectra in each step of the surface modification of the Ag nanoparticles in atmosphere environment. A spectrophotometer was used to measure the extinction spectrum of our proposed nanochip. The results obtained indicate a better sensitivity for our current nanochip than that of the other reported LSPR-based nanochips. Theoretical computational numerical simulation is also carried out with a discrete dipole approximation algorithm. Our computational results are in agreement with the corresponding experimental spectrum. This type of nanochip may have potential utility in many applications, including medical science, biological fields and biochemical analysis.
本文描述了一种由菱形纳米颗粒组成的具有矩形分布阵列的新型银（Ag）纳米结构。该结构具有明显的优势，即具有很强的热点，其信号强度比先前报道的传统三角形结构高得多。它极大地增强了局域表面等离子体共振（LSPR）效应。此外，应用臂长更长的抗原以增强抗原和抗体的结合信号。我们在大气环境中对银纳米颗粒表面修饰的每个步骤进行了LSPR诱导消光光谱的实验。使用分光光度计测量我们提出的纳米芯片的消光光谱。获得的结果表明，我们当前的纳米芯片比其他报道的基于LSPR的纳米芯片具有更好的灵敏度。还使用离散偶极近似算法进行了理论计算数值模拟。我们的计算结果与相应的实验光谱一致。这种类型的纳米芯片在许多应用中可能具有潜在用途，包括医学、生物领域和生化分析。
