一系列红霉素类似物的催化位点选择性合成与评价
Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs.
作者信息
Lewis Chad A, Merkel Janie, Miller Scott J
机构信息
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.
出版信息
Bioorg Med Chem Lett. 2008 Nov 15;18(22):6007-11. doi: 10.1016/j.bmcl.2008.09.019. Epub 2008 Sep 9.
Abstract
The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.
摘要
描述了一系列红霉素A（EryA，2）类似物的生成。在本研究中，我们比较了两种基于肽的催化剂——一种最初从催化剂筛选中鉴定出来（5）及其对映体（对映体-5）——用于EryA的选择性官能化。对这些半合成类似物用两种细菌菌株进行了最低抑菌浓度（MIC）评估，并与未官能化的EryA进行了比较。
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