Rau T T, Hartmann A, Dietmaier W, Schmitz J, Hohenberger W, Hofstaedter F, Katenkamp K
Institute of Pathology, University Hospital Erlangen, Erlangen, Germany.
J Clin Pathol. 2008 Oct;61(10):1136-7. doi: 10.1136/jcp.2008.059162.
Mesenchymal tumours other than gastrointestinal stromal tumours are rare in the stomach. Nevertheless it is important to incorporate them into the differential diagnosis. Plexiform angiomyxoid myofibroblastic tumour is a recently described new entity of a presumably benign mesenchymal gastric tumour. This report presents what is believed to be the third case of this tumour. The tumour is characterised by bland spindle cells in a plexiform pattern, a mucinous extracellular matrix and a network of thin blood vessels. These findings are completely in line with the two previous reported cases. There was a strong positivity for alpha-smooth muscle actin and a low proliferation index (<2%). The tumour had no C-KIT or CD34 expression and no mutation in the C-KIT and PDFGRalpha genes. Plexiform angiomyxoid myofibroblastic tumour may present a new mesenchymal tumour entity in the stomach.
除胃肠道间质瘤外，间叶性肿瘤在胃中较为罕见。然而，将它们纳入鉴别诊断很重要。丛状血管黏液样肌成纤维细胞瘤是一种最近描述的可能为良性的胃间叶性肿瘤新实体。本报告展示了据信是该肿瘤的第三例病例。该肿瘤的特征是呈丛状排列的温和梭形细胞、黏液样细胞外基质和细血管网络。这些发现与之前报道的两例病例完全一致。α-平滑肌肌动蛋白呈强阳性，增殖指数低（<2%）。该肿瘤无C-KIT或CD34表达，C-KIT和PDFGRα基因无突变。丛状血管黏液样肌成纤维细胞瘤可能是胃中的一种新的间叶性肿瘤实体。
