Lee Jae K, Zheng Binhai
Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0691, USA.
Restor Neurol Neurosci. 2008;26(2-3):175-82.
The use of genetically modified mice to study axon regeneration after spinal cord injury has served as a useful in vivo model for both loss-of-function and gain-of-function analysis of candidate proteins. This review discusses the impact of genetically modified mice on axon regeneration after spinal cord injury in the context of axon growth inhibition by myelin, the glial scar, and chemorepellent molecules. We also discuss the use of mice which transgenically express fluorescent proteins in specific axons for increasing our understanding of how spinal cord axons behave after injury.
利用基因工程小鼠研究脊髓损伤后的轴突再生，已成为一种用于对候选蛋白进行功能丧失和功能获得分析的有用体内模型。本综述在髓磷脂、胶质瘢痕和化学排斥分子对轴突生长抑制的背景下，讨论了基因工程小鼠对脊髓损伤后轴突再生的影响。我们还讨论了在特定轴突中转基因表达荧光蛋白的小鼠的应用，以增进我们对脊髓轴突损伤后行为的理解。
