Rees J H, Woodhead M A, Sheppard M N, du Bois R M
Interstitial Lung Disease Unit, Royal Brompton and National Heart Hospital, London, U.K.
Respir Med. 1991 May;85(3):243-6. doi: 10.1016/s0954-6111(06)80088-0.
We describe three patients with rheumatoid arthritis who presented with non-specific pulmonary symptoms, a restrictive defect in lung function and bilateral changes on chest radiograph. Lung histology showed characteristic features of cryptogenic organising pneumonitis and treatment with steroids produced significant improvement. The clinical and laboratory features of cryptogenic organising pneumonitis (otherwise known as bronchiolitis obliterans organising pneumonia, 'BOOP') are discussed and compared with those of bronchiolitis obliterans with which the condition should not be confused. Cryptogenic organising pneumonitis should be considered as one of the pulmonary manifestations of rheumatoid arthritis, but lung biopsy is essential to make the diagnosis.
我们描述了三名类风湿性关节炎患者，他们表现出非特异性肺部症状、肺功能限制性缺陷以及胸部X光片上的双侧改变。肺部组织学显示为隐源性机化性肺炎的特征性表现，使用类固醇治疗后有显著改善。本文讨论了隐源性机化性肺炎（又称闭塞性细支气管炎机化性肺炎，“BOOP”）的临床和实验室特征，并与不应与之混淆的闭塞性细支气管炎的特征进行了比较。隐源性机化性肺炎应被视为类风湿性关节炎的肺部表现之一，但肺活检对于做出诊断至关重要。
