Bellomo R, Finlay M, McLaughlin P, Tai E
Department of Respiratory Medicine, Monash Medical Centre, Melbourne, Victoria, Australia.
Thorax. 1991 Aug;46(8):554-8. doi: 10.1136/thx.46.8.554.
Cryptogenic organising pneumonitis (bronchiolitis obliterans organising pneumonia) is an uncommon condition that often responds to steroids. It is characterised clinically by constitutional symptoms, pathologically by intra-alveolar organising fibrosis, and radiologically by patchy pulmonary infiltrates. Its full clinical spectrum and course are only partially described and understood. Six patients are described, seen over three years, with considerably diverse clinical and radiological presentations (two had diffuse lung infiltrates, two had peripheral lung infiltrates, and two had localised lobar involvement) and with very varying severity of disease (two with a life threatening illness, three with appreciable subacute constitutional symptoms, and one with mild symptoms). It is concluded that cryptogenic organising pneumonitis can present in various ways. A set of diagnostic criteria are proposed which will help in the recognition of this syndrome, which is probably underdiagnosed.
隐源性机化性肺炎（闭塞性细支气管炎机化性肺炎）是一种不常见的疾病，通常对类固醇治疗有反应。其临床特征为全身症状，病理特征为肺泡内机化性纤维化，放射学特征为斑片状肺部浸润。其完整的临床谱和病程仅得到部分描述和了解。本文描述了6例患者，这些患者在3年期间就诊，临床表现和放射学表现差异很大（2例有弥漫性肺部浸润，2例有外周肺部浸润，2例有局限性肺叶受累），疾病严重程度也非常不同（2例患有危及生命的疾病，3例有明显的亚急性全身症状，1例有轻度症状）。得出的结论是，隐源性机化性肺炎可以有多种表现形式。提出了一套诊断标准，这将有助于识别这种可能诊断不足的综合征。
