Furusawa S, Fujimura T, Hayasaka S, Kawauchi H, Sasaki K, Takayanagi Y
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Res Commun Chem Pathol Pharmacol. 1991 Jul;73(1):75-86.
The effect of sodium chloride on the cytotoxicity of 4'-O-tetrahydropyranyldoxorubicin (pirarubicin), a novel anthracycline derivative, was investigated on P388 mouse leukemia cells in vitro. The modifications in efficiency of uptake and killing action of pirarubicin were found to be dependent on the ionic strength of the medium. The relationship between intracellular drug accumulation into cells and cell killing was pointed out.
研究了氯化钠对新型蒽环类衍生物4'-O-四氢吡喃基阿霉素（吡柔比星）体外对P388小鼠白血病细胞细胞毒性的影响。发现吡柔比星摄取效率和杀伤作用的改变取决于培养基的离子强度。指出了细胞内药物积累与细胞杀伤之间的关系。
