Hiura Yuhei, Tachibana Hirofumi, Arakawa Ryo, Aoyama Natsuki, Okabe Masaaki, Sakai Midori, Yamada Koji
Faculty of Agriculture, Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812-8581, Japan.
J Nutr Biochem. 2009 Aug;20(8):607-13. doi: 10.1016/j.jnutbio.2008.06.004. Epub 2008 Sep 27.
In contrast to extensive studies on tocopherols, very little is understood about tocotrienols (T3). We evaluated the antitumor activities of gamma-T3 and delta-T3 in murine hepatoma MH134 cells in vitro and in vivo. We found that delta-T3 inhibited the growth of MH134 cells more strongly than gamma-T3 by inducing apoptosis. In C3H/HeN mice implanted with MH134, it was found that gamma-T3 and delta-T3 feeding significantly delayed tumor growth. On the other hand, both T3 had no significant effect on body weight, normal-tissue weight and immunoglobulin levels. Intriguingly, we found that T3 was detected in tumor, but not in normal tissues. These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3.
与对生育酚的广泛研究相比，人们对生育三烯酚（T3）的了解非常少。我们在体外和体内评估了γ-T3和δ-T3对小鼠肝癌MH134细胞的抗肿瘤活性。我们发现，δ-T3通过诱导细胞凋亡比γ-T3更强烈地抑制MH134细胞的生长。在植入MH134的C3H/HeN小鼠中，发现喂食γ-T3和δ-T3显著延迟了肿瘤生长。另一方面，两种T3对体重、正常组织重量和免疫球蛋白水平均无显著影响。有趣的是，我们发现肿瘤中可检测到T3，但正常组织中未检测到。据我们所知，这些结果首次证明了γ-T3和δ-T3在肿瘤中的特异性积累，并表明T3积累对T3的抗肿瘤活性至关重要。
