Larsson L O, Skoogh B E, Bentzon M W, Magnusson M, Olofson J, Taranger J, Lind A
Department of Pulmonary Medicine, University of Göteborg, Sweden.
Tubercle. 1991 Mar;72(1):37-42. doi: 10.1016/0041-3879(91)90022-k.
Non-BCG-vaccinated preschool children (4 or 5 years of age) were simultaneously tested on separate arms with a 2 IU PPD RT23 and 0.1 microgram Mycobacterium avium sensitin RS10 or 0.1 microgram Mycobacterium scrofulaceum sensitin RS95. None of the 762 children had any known exposure to tuberculosis. A total of 8.8% reacted with an induration (greater than or equal to 3 mm to PPD RT23 while 2% reacted with greater than or equal to 6 mm. Half the children were tested with M. avium sensitin: 18.9 and 7.8% reacted when 3 and 6 mm cut-off points, respectively, were taken. The remaining children were tested with M. scrofulaceum sensitin: 18.4 and 6.3%, respectively, reacted. In a previous study of schoolchildren aged 8 or 9 years, reactions to sensitins were considerably more frequent. Thus, sensitisation by atypical mycobacteria seems to increase from the preschool to the early school age. This finding probably reflects a continuous exposure of the children to atypical mycobacteria from various sources. The preschool children with a reaction to PPD RT23 greater than or equal to 6 mm were examined and chest X-rays were performed. All children were healthy but one child had enlarged lymph nodes in the mediastinum and abdomen. It cannot be excluded that these pathological findings were caused by atypical mycobacteria.
未接种卡介苗的学龄前儿童（4或5岁）在不同手臂上同时接受2 IU PPD RT23以及0.1微克鸟分枝杆菌变应原RS10或0.1微克瘰疬分枝杆菌变应原RS95的检测。762名儿童均无已知的结核接触史。共有8.8%的儿童出现硬结反应（对PPD RT23硬结直径大于或等于3 mm），而2%的儿童硬结直径大于或等于6 mm。一半儿童接受鸟分枝杆菌变应原检测：当分别以3 mm和6 mm为判断标准时，反应率分别为18.9%和7.8%。其余儿童接受瘰疬分枝杆菌变应原检测：反应率分别为18.4%和6.3%。在之前一项针对8或9岁学童的研究中，对变应原的反应更为常见。因此，非典型分枝杆菌致敏似乎从学龄前到学龄早期有所增加。这一发现可能反映了儿童持续接触来自各种来源的非典型分枝杆菌。对PPD RT23反应硬结直径大于或等于6 mm的学龄前儿童进行了检查并拍摄了胸部X光片。所有儿童均健康，但有一名儿童纵隔和腹部淋巴结肿大。不能排除这些病理表现是由非典型分枝杆菌引起的。
