Mamo W, Lindahl M, Jonsson P
Department of Veterinary Microbiology, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Vet Microbiol. 1991 May;27(3-4):371-84. doi: 10.1016/0378-1135(91)90161-8.
The virulence towards mice of Staphylococcus aureus strains from bovine mastitis was enhanced upon growth in milk whey compared to homologous organisms grown in tryptic soy broth (TSB). In the mouse mastitis model, S. aureus grown in milk whey caused more severe lesions than homologous strains grown in TSB. Staphylococcus aureus strain F1440 grown in milk whey induced 75% mortality and local necrotic reaction in subcutaneously inoculated mice, whereas the homologous strain grown in TSB caused only 5% mortality and slight skin reaction. Extracellular capsule on milk whey-grown, S. aureus could not be demonstrated. However, diffuse type colony morphology could be correlated with an increased virulence of S. aureus towards mice.
与在胰蛋白胨大豆肉汤（TSB）中生长的同源金黄色葡萄球菌相比，来自牛乳腺炎的金黄色葡萄球菌菌株在乳清中生长后对小鼠的毒力增强。在小鼠乳腺炎模型中，在乳清中生长的金黄色葡萄球菌比在TSB中生长的同源菌株引起更严重的病变。在乳清中生长的金黄色葡萄球菌菌株F1440在皮下接种的小鼠中诱导了75%的死亡率和局部坏死反应，而在TSB中生长的同源菌株仅导致5%的死亡率和轻微的皮肤反应。在乳清中生长的金黄色葡萄球菌上未检测到细胞外荚膜。然而，弥漫型菌落形态可能与金黄色葡萄球菌对小鼠的毒力增加有关。
