Lu Haiyan, Castells Salvador, Hagerty Dawn, Quintos Jose Bernardo
Pediatric Endocrine Division, Department of Pediatrics, Children's Hospital at SUNY Downstate Medical Center, Brooklyn, NY, USA.
J Pediatr Endocrinol Metab. 2008 Aug;21(8):729-36. doi: 10.1515/jpem.2008.21.8.729.
To evaluate glycemic excursions in adolescents with poorly controlled type 2 diabetes mellitus (DM2).
Seventeen adolescents (12 F/5 M) underwent glucose monitoring for 3 days using a continuous glucose monitoring system (CGMS). Glucose measurements were divided into periods of euglycemia, hyperglycemia, and hypoglycemia. The percentage of each period, average glucose concentration per 24 h, day and night, the number of excursions, and area under the curve (AUC) of glucose >150 mg/dl and <70 mg/dl were calculated.
On average, patients remained in euglycemia for 28.5%, hyperglycemia for 70%, and hypoglycemia 1.3% of the total day. Hyperglycemic excursions were more frequent during the day. Hypoglycemic events were more frequent during the night. 24-h average glucose, duration of glucose >150 mg/dl, and AUC >150 mg/dl correlate with HbA1c and fructosamine to varying degrees.
Continuous glucose monitoring provide valuable information on glucose excursions in adolescents with poorly controlled DM2 and may be helpful in improving metabolic control of poorly controlled adolescents with DM2.
评估2型糖尿病（DM2）控制不佳的青少年的血糖波动情况。
17名青少年（12名女性/5名男性）使用连续血糖监测系统（CGMS）进行了3天的血糖监测。血糖测量分为血糖正常、高血糖和低血糖期。计算每个时期的百分比、每24小时、白天和晚上的平均血糖浓度、波动次数以及血糖>150 mg/dl和<70 mg/dl的曲线下面积（AUC）。
平均而言，患者全天处于血糖正常状态的时间占28.5%，高血糖状态占70%，低血糖状态占1.3%。白天高血糖波动更频繁。夜间低血糖事件更频繁。24小时平均血糖、血糖>150 mg/dl的持续时间以及AUC>150 mg/dl与糖化血红蛋白（HbA1c）和果糖胺在不同程度上相关。
连续血糖监测为DM2控制不佳的青少年的血糖波动提供了有价值的信息，可能有助于改善DM2控制不佳的青少年的代谢控制。
