Lee In-Kyoung, Lee Jeong-Hyung, Hwang Eui Il, Yun Bong-Sik
Division of Biotechnology, College of Environmental and Bioresources Sciences, Chonbuk National University, Jeonju, Korea.
Chem Pharm Bull (Tokyo). 2008 Oct;56(10):1483-5. doi: 10.1248/cpb.56.1483.
Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4-guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.
从日本窃衣果实的甲醇提取物中分离出三种新的愈创木烷型倍半萜，以及一种已知化合物托里林（1）。通过光谱方法确定它们的结构分别为11-乙酰氧基-8-异丁酰基-4-愈创木烯-3-酮（2）、11-乙酰氧基-8-甲基丙烯酰基-4-愈创木烯-3-酮（3）和11-乙酰氧基-8-丙酰基-4-愈创木烯-3-酮（4）。这些化合物抑制脂多糖（LPS）诱导的小鼠巨噬细胞RAW 264.7细胞中一氧化氮的产生。
