Antonelli Alessandro, Fazzi Piera, Fallahi Poupak, Ferrari Silvia Martina, Grosso Mariano, Boni Giuseppe, Ferrannini Ele, Mariani Giuliano
Metabolism Unit, Department of Internal Medicine, University of Pisa and CNR Institute of Clinical Physiology, Via Roma, 67, 56126, Pisa, Italy.
Eur J Nucl Med Mol Imaging. 2009 Jan;36(1):137-43. doi: 10.1007/s00259-008-0932-9. Epub 2008 Sep 9.
To evaluate the association of gallium-67 ((67)Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients).
Eighty-four S patients were evaluated by a complete thyroid work-up (neck ultrasound, circulating thyroid hormones and anti-thyroid antibodies, fine-needle aspiration).
In S patients with (67)Ga thyroid uptake (respect those without): serum thyroid-stimulating hormone, the titre of anti-thyroid peroxidase (AbTPO) and/or anti-thyroglobulin antibodies (AbTg), and the prevalence of S patients with hypothyroidism or with positive AbTg or AbTPO was significantly higher; a thyroid hypoechoic pattern was more frequent. The prevalence of thyroid nodules was not significantly different between the two groups. Two cases of papillary thyroid cancer were observed in S patients without (67)Ga thyroid uptake, whilst no case in those with (67)Ga thyroid uptake.
(67)Ga thyroid uptake is associated with the presence of aggressive autoimmune thyroiditis and hypothyroidism in S patients; thyroid function and ultrasonography should be performed in the presence of (67)Ga thyroid uptake.
评估结节病患者（S患者）中枸橼酸镓-67（⁶⁷Ga）甲状腺摄取与甲状腺疾病存在之间的关联。
通过完整的甲状腺检查（颈部超声、循环甲状腺激素和抗甲状腺抗体、细针穿刺）对84例S患者进行评估。
在有⁶⁷Ga甲状腺摄取的S患者中（相对于无摄取者）：血清促甲状腺激素、抗甲状腺过氧化物酶（AbTPO）和/或抗甲状腺球蛋白抗体（AbTg）的滴度，以及甲状腺功能减退或AbTg或AbTPO阳性的S患者的患病率显著更高；甲状腺低回声模式更常见。两组之间甲状腺结节的患病率无显著差异。在无⁶⁷Ga甲状腺摄取 的S患者中观察到2例甲状腺乳头状癌，而在有⁶⁷Ga甲状腺摄取的患者中未观察到病例。
⁶⁷Ga甲状腺摄取与S患者中侵袭性自身免疫性甲状腺炎和甲状腺功能减退的存在有关；在有⁶⁷Ga甲状腺摄取的情况下应进行甲状腺功能和超声检查。
