Comer G M, Ozick L A, Sachdev R K, Kumar S, Taunk J L, Smith J A, Lee T P, Clain D J
Department of Medicine, Harlem Hospital Center, New York, New York.
Am J Gastroenterol. 1991 Sep;86(9):1232-4.
The medical records and liver biopsies of nine sickle cell patients with chronically elevated liver function tests were retrospectively reviewed to determine the etiology of chronic liver disease. There were eight women and one man with a mean age of 30 yr. All patients had hemoglobin SS. Eight patients were referred for elevated aminotransferases and one for an elevated alkaline phosphatase. Hemosiderosis was present in all of the biopsies. Two patients had cirrhosis. Chronic hepatitis was noted in two patients, and five patients had cholestasis. Two patients had serologic markers demonstrating HBV exposure but no patients were HBsAg positive. Erythrophagocytosis, sinusoidal dilatation, and Kupffer cell hyperplasia were present in all of the liver biopsies. Transfusion-related causes were the most common significant pathologic findings in our patients, and appeared to be the etiologies of chronic liver disease in sickle cell patients.
对9例肝功能检查长期升高的镰状细胞病患者的病历和肝活检进行回顾性分析，以确定慢性肝病的病因。患者中有8名女性和1名男性，平均年龄30岁。所有患者均为血红蛋白SS型。8例患者因转氨酶升高就诊，1例因碱性磷酸酶升高就诊。所有活检均发现有含铁血黄素沉着症。2例患者有肝硬化。2例患者有慢性肝炎，5例患者有胆汁淤积。2例患者血清学标志物显示曾接触乙肝病毒，但无患者HBsAg阳性。所有肝活检均可见红细胞吞噬现象、肝血窦扩张和库普弗细胞增生。输血相关原因是我们患者中最常见的重要病理表现，似乎是镰状细胞病患者慢性肝病的病因。
