Paetau A, Haltia M
Acta Neuropathol. 1976 Oct 15;36(2):185-91. doi: 10.1007/BF00685280.
Necropsy of a patient who died of uremia complicating juvenile diabetes revealed selective calcification of the perineurial sheaths in the sciatic nerves. The calcium phosphate deposits were limited to the outer layers of the perineurium while the innermost lamellae were free. Structural analysis, including electron diffraction and X-ray microanalysis, showed electron-dense, spicular deposits, which were composed mainly of finely crystallized hydroxyapatite. The end-stage diabetic nephropathy of the patient was associated with an extremely high calcium phosphorus ion product known to favour metastatic calcification. The mechanism of the selective localization of the calcium phosphate deposits to the outer layers of the perineurial sheaths is discussed with reference to the structure and suggested barrier function of the perineurium in regard to phosphate ions.
一名死于尿毒症并伴有青少年糖尿病的患者尸检显示，坐骨神经的神经束膜出现选择性钙化。磷酸钙沉积物局限于神经束膜的外层，而最内层薄片则未受影响。包括电子衍射和X射线微分析在内的结构分析表明，存在电子致密的针状沉积物，其主要由微晶状羟基磷灰石组成。该患者的终末期糖尿病肾病与已知有利于转移性钙化的极高钙磷离子乘积有关。结合神经束膜的结构以及其对磷酸根离子的推测屏障功能，讨论了磷酸钙沉积物在神经束膜外层选择性定位的机制。
