Terao E, Corman B, van den Bosch de Aguilar P
Laboratoire de Biologie Cellulaire, Université Catholique de Louvain, Belgium.
Acta Neuropathol. 1991;81(5):546-51. doi: 10.1007/BF00310136.
A spontaneous mineralization of the sciatic nerve of senescent specific pathogen-free-bred rats (aged 42 months) is reported. Deposits were found in the endoneurium of different branches of the nerve at mid-thigh level. They appeared as small discrete deposits or as large tubular-shaped concretions, probably formed by the growth and merger of the smaller deposits. Some of the concretions were found in close proximity to blood vessels. Deposits consisted of dense aggregations of randomly entangled spicules spreading within bundles of collagen fibrils. Calcium was detected by histochemistry and X-ray dispersion microanalysis. Phosphorus was also found, possibly associated with calcium to form hydroxyapatite.
据报道，在42月龄的衰老无特定病原体饲养大鼠的坐骨神经中出现了自发矿化现象。在大腿中部水平的神经不同分支的神经内膜中发现了沉积物。它们表现为小的离散沉积物或大的管状结石，可能是由较小沉积物的生长和合并形成的。一些结石靠近血管。沉积物由在胶原纤维束内随机缠结的针状晶体的密集聚集体组成。通过组织化学和X射线色散微分析检测到了钙。还发现了磷，可能与钙结合形成羟基磷灰石。
