Adachi Masahiro, Takayanagi Ryoichi
Kyushu University, Graduate School of Medical Science, Department of Medicine and Bioregulatory Science.
Clin Calcium. 2008 Oct;18(10):1451-9.
Androgen inhibits osteoclastic bone resorption with increase of bone formation through androgen receptor in bone tissue. Anabolic steroids are synthetic derivates of testoterone. Anobolic steroids have favorable anabolic actions, lessening virilizing effects. Several anabolic steroids have been synthesized and some of them have been approved as a drug for anti osteoporosis. Anabolic steroids have revealed the increased bone mineral content or bone mineral density at the radius, and the lumbar spine in osteoporosis patients. Anabolic steroids have also decreased fat mass with increase of lean body mass and muscle mass, and lessened bone pain in osteoporosis patients having bone fracture, which seem to be favorable effects for especially elder osteoporosis patients. But in recent years the number of osteoporosis patients treated with anabolic steroids has been decreasing. Furthermore recently few clinical trials about the effect of anabolic steroids on osteoporosis have been reported, and prospective study for bone fracture using anabolic steroids has not reported yet. We would like to expect additional effects except on bone formation will enhance the frequency in use of anabolic steroids, and the prospective clinical study about the prevention against bone fracture will be reported in the future.
雄激素通过骨组织中的雄激素受体抑制破骨细胞的骨吸收并增加骨形成。合成代谢类固醇是睾酮的合成衍生物。合成代谢类固醇具有良好的合成代谢作用，可减轻男性化作用。已经合成了几种合成代谢类固醇，其中一些已被批准作为抗骨质疏松药物。合成代谢类固醇已显示骨质疏松症患者桡骨和腰椎的骨矿物质含量或骨矿物质密度增加。合成代谢类固醇还减少了脂肪量，增加了瘦体重和肌肉量，并减轻了患有骨折的骨质疏松症患者的骨痛，这对老年骨质疏松症患者似乎是有益的效果。但近年来，使用合成代谢类固醇治疗的骨质疏松症患者数量一直在减少。此外，最近很少有关于合成代谢类固醇对骨质疏松症影响的临床试验报道，且尚未有关于使用合成代谢类固醇预防骨折的前瞻性研究报道。我们期望除了对骨形成的作用外，其他额外的作用将提高合成代谢类固醇的使用频率，并且未来将报道关于预防骨折的前瞻性临床研究。
