d'Espiney Amaro Carla, Montalvão Pedro, Henriques Pedro, Magalhães Miguel, Olias João
Otorhinolaryngology Department, Portuguese Institute of Oncology Hospital in Lisbon (IPOLFG-EPE), Lisbon, Portugal.
Eur Arch Otorhinolaryngol. 2009 Jun;266(6):833-8. doi: 10.1007/s00405-008-0822-6. Epub 2008 Oct 2.
The objectives of our study were to characterize nasopharyngeal carcinoma patients in the Portuguese Institute of Oncology Hospital in Lisbon (IPOLFG) and identify the main factors that interfere with patients survival rate. We performed a retrospective study involving 157 patients (65% male and 35% female) between the years 2000 and 2005, and a histological classification according to Health World Organization. We constructed a Kaplan-Meier survival curve for the studied patients and evaluated the significance of the different studied factors with a Pearson correlation study. With an average age of 53 years, most of the carcinomas were type III (58%), followed by type II (30%) and at last type I (8%). Fifty-one of carcinomas were in stage IV at time of diagnosis. Ninety-five patients (60%) had remission. Five-year actuarial survival rate of all patients was 65.1%. There was a significant difference (P = 0.033) in the actuarial survival rate of staged IV patients treated with adjuvant chemotherapy. Undifferentiated nasopharyngeal carcinoma is the most frequent type in our geographic area. Chemotherapy improves survival rate, mainly in late stages.
我们研究的目的是对里斯本葡萄牙肿瘤研究所医院（IPOLFG）的鼻咽癌患者进行特征描述，并确定影响患者生存率的主要因素。我们进行了一项回顾性研究，纳入了2000年至2005年间的157例患者（65%为男性，35%为女性），并根据世界卫生组织进行了组织学分类。我们为研究患者构建了Kaplan-Meier生存曲线，并通过Pearson相关性研究评估了不同研究因素的显著性。患者平均年龄为53岁，大多数癌症为III型（58%），其次是II型（30%），最后是I型（8%）。51例癌症在诊断时处于IV期。95例患者（60%）病情缓解。所有患者的五年精算生存率为65.1%。接受辅助化疗的IV期患者的精算生存率存在显著差异（P = 0.033）。未分化鼻咽癌是我们所在地理区域最常见的类型。化疗可提高生存率，主要是在晚期。
