van Eijk Anna M, Ouma Peter O, Williamson John, Ter Kuile Feiko O, Parise Monica, Otieno Kephas, Hamel Mary J, Ayisi John G, Kariuki Simon, Kager Piet A, Slutsker Laurence
Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
J Infect Dis. 2008 Nov 15;198(10):1550-3. doi: 10.1086/592715.
Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasma folate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.
http://www.clinicaltrials.gov identifier: NCT00130065.
周效磺胺-乙胺嘧啶（SP）可抑制疟原虫的叶酸代谢。我们调查了孕妇叶酸水平与SP治疗失败之间的关联。分析了一项评估叶酸补充剂对467名孕妇SP治疗失败影响的试验数据。在入组时和第7天测定血浆叶酸水平。基线叶酸水平高、寄生虫密度高以及年龄<20岁是SP治疗失败的危险因素。高剂量（每日5毫克）叶酸补充剂或第7天叶酸水平高是独立危险因素。因此，接受SP治疗的孕妇应接受低/中剂量叶酸补充剂。
http://www.clinicaltrials.gov 标识符：NCT00130065。
