Chong P N, Ong B, Chan R
Department of Medicine, National University Hospital, Singapore.
Ann Acad Med Singap. 1991 Mar;20(2):223-7.
Patients with hemifacial spasm (N = 25), blepharospasm (n = 8), and benign eyelid fasciculation (n = 2) were treated with botulinum toxin injections (PHLS, Porton Down, England). All patients reported substantial symptomatic relief. Marked improvement was seen in fifteen patients with hemifacial spasm and six patients with blepharospasm. Benign eyelid fasciculation was completely abolished. Beneficial effects was evident two to three days after injections, became maximum at one week, and remained effective for up to six months. Side effects were transitory and mild. They included periorbital edema, mild diplopia, ptosis and facial weakness. Only in two patients was ptosis unacceptable. Severity of side effects was dose-related. Reinjections had similar efficacy. Botulinum toxin therapy is a safe and effective treatment for these facial dyskinesias and should be considered a viable alternative to surgical procedures.
患有半面痉挛（N = 25）、眼睑痉挛（n = 8）和良性眼睑肌束震颤（n = 2）的患者接受了肉毒杆菌毒素注射治疗（PHLS，英国波顿唐）。所有患者均报告症状明显缓解。15例半面痉挛患者和6例眼睑痉挛患者有显著改善。良性眼睑肌束震颤完全消除。注射后两到三天效果明显，一周时达到最大效果，并可持续长达六个月有效。副作用短暂且轻微。包括眶周水肿、轻度复视、上睑下垂和面部无力。只有两例患者的上睑下垂难以接受。副作用的严重程度与剂量相关。再次注射有类似疗效。肉毒杆菌毒素疗法是治疗这些面部运动障碍的一种安全有效的方法，应被视为手术治疗的一种可行替代方案。
