Shorr N, Seiff S R, Kopelman J
Am J Ophthalmol. 1985 May 15;99(5):542-6. doi: 10.1016/s0002-9394(14)77954-1.
Twenty-two patients, 17 with benign essential blepharospasm and five with hemifacial spasm, received botulinum toxin by subcutaneous injections in the eyelids and eyebrows. All 22 patients received a standard treatment of 12.5 units of botulinum toxin per side at each injection session. The orbicularis oculi muscle showed pronounced weakness after injection and the spasms decreased. Spasms often recurred despite persistent orbicularis oculi muscle weakness. Side effects were minimal. All patients received some relief, which generally lasted six to 12 weeks.
22名患者，其中17名患有良性特发性眼睑痉挛，5名患有半面痉挛，通过皮下注射肉毒杆菌毒素于眼睑和眉毛处。所有22名患者在每次注射时每侧接受12.5单位肉毒杆菌毒素的标准治疗。注射后眼轮匝肌显示出明显的无力，痉挛减轻。尽管眼轮匝肌持续无力，但痉挛仍经常复发。副作用极小。所有患者均得到了一定程度的缓解，这种缓解通常持续6至12周。
