肉毒杆菌A毒素治疗面肌痉挛和眼睑痉挛。
Botulinum a toxin treatment of hemifacial spasm and blepharospasm.
作者信息
Park Y C, Lim J K, Lee D K, Yi S D
机构信息
Department of Neurology, Keimyung University School of Medicine, Taegu, Korea.
出版信息
J Korean Med Sci. 1993 Oct;8(5):334-40. doi: 10.3346/jkms.1993.8.5.334.
We studied the effects of botulinum A toxin in 101 patients with hemifacial spasm and 11 patients with blepharospasm in an open trial and double blind manner. All patients in the open trial and 6 patients in the double blind trial improved after the first injection of botulinum toxin. There was no improvement with placebo. The peak effect ranged from one to 6 days after injection and mean peak effect was 3.6 days in blepharospasm, and 4 days in hemifacial spasm. Of 144 treatments, 98.6% had excellent results, (below grade I). The duration of beneficial effect ranged 11 to 40 weeks (mean 16.5 weeks) in hemifacial spasm and 9 to 30 weeks (mean 14.2 weeks) in blepharospasm. Complications were encountered in 63.4% in hemifacial spasm and 72.7% in blepharospasm. The common side effects were dry eyes, mouth droop, ptosis and lid edema in order of frequency. These side effects were mild and resolved spontaneously in 1 to 3 weeks. Botulinum A toxin therapy is effective and convenient, and the treatment of choice for patients with hemifacial spasm and blepharospasm.
我们以开放试验和双盲方式研究了A型肉毒杆菌毒素对101例面肌痉挛患者和11例眼睑痉挛患者的疗效。开放试验中的所有患者以及双盲试验中的6例患者在首次注射肉毒杆菌毒素后病情均有改善。使用安慰剂则无改善。注射后1至6天出现峰值效应，眼睑痉挛的平均峰值效应为3.6天，面肌痉挛为4天。在144次治疗中，98.6%的治疗效果极佳（一级以下）。面肌痉挛的有益效果持续时间为11至40周（平均16.5周），眼睑痉挛为9至30周（平均14.2周）。面肌痉挛患者的并发症发生率为63.4%，眼睑痉挛患者为72.7%。常见的副作用依次为干眼、口角下垂、上睑下垂和眼睑水肿。这些副作用较轻，1至3周内可自行缓解。A型肉毒杆菌毒素治疗有效且方便，是面肌痉挛和眼睑痉挛患者的首选治疗方法。
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