Renner Marianne, Specht Christian G, Triller Antoine
Inserm U789, Biologie Cellulaire de la Synapse, ENS, Paris, France.
Curr Opin Neurobiol. 2008 Oct;18(5):532-40. doi: 10.1016/j.conb.2008.09.009. Epub 2008 Oct 23.
The activity of neurotransmitter receptors determines the strength of synaptic transmission. Therefore, the clustering of receptors at synapses is an important mechanism underlying synaptic plasticity. The dynamic exchange of receptors between synaptic and extrasynaptic membranes is dependent on their interaction with synaptic scaffold proteins. Here, we review the recent advances and emerging concepts related to the dynamics of synaptic proteins at inhibitory and excitatory synapses. These include the imaging techniques that enable the study of protein dynamics in cells, the differences and similarities of receptor dynamics at excitatory and inhibitory synapses, the relationship between the exchange of receptor and scaffold proteins, as well as the role of receptor fluxes in the modulation of synaptic strength.
神经递质受体的活性决定了突触传递的强度。因此，受体在突触处的聚集是突触可塑性的重要机制。受体在突触膜和突触外膜之间的动态交换取决于它们与突触支架蛋白的相互作用。在这里，我们综述了与抑制性和兴奋性突触处突触蛋白动力学相关的最新进展和新兴概念。这些包括能够研究细胞中蛋白质动力学的成像技术、兴奋性和抑制性突触处受体动力学的异同、受体与支架蛋白交换之间的关系，以及受体通量在调节突触强度中的作用。
