De Paepe K, Houben E, Adam R, Hachem J-P, Roseeuw D, Rogiers V
Department of Toxicology, Dermato-Cosmetology and Pharmacognosy, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Skin Pharmacol Physiol. 2009;22(1):8-14. doi: 10.1159/000159772. Epub 2008 Oct 3.
In the present work, nasolabial skin condition and the influence of seasonal changes during autumn and winter were studied in 16 healthy female volunteers. Apart from visual scoring of erythema and skin scaliness, transepidermal water loss (TEWL), skin hydration, apparent skin pH, skin colour and skin desquamation were biophysically measured. The study results showed that nasolabial TEWL was significantly higher during wintertime than in autumn. Also skin colour measurements and squamometry scorings revealed higher values, indicating a more reddish and scaly nasolabial skin during winter compared to autumn. Results from tape stripping and skin surface lipid analysis by high-performance thin-layer chromatography demonstrated significant differences for triglycerides and cholesterol esters, indicating a functionally inferior hydrolipidic layer during the winter season.
在本研究中，对16名健康女性志愿者的鼻唇皮肤状况以及秋冬季节变化的影响进行了研究。除了对红斑和皮肤鳞屑进行视觉评分外，还对经表皮水分流失（TEWL）、皮肤水合作用、表观皮肤pH值、皮肤颜色和皮肤脱屑进行了生物物理测量。研究结果表明，冬季鼻唇部位的TEWL显著高于秋季。皮肤颜色测量和鳞屑测量评分也显示出较高的值，表明与秋季相比，冬季鼻唇皮肤更红且鳞屑更多。胶带剥离和高效薄层色谱法进行的皮肤表面脂质分析结果显示，甘油三酯和胆固醇酯存在显著差异，表明冬季脂质水合层功能较差。
